Journal of the California Cannabis Research Medical
Which Conditions are Californians Actually
Treating With Cannabis?
By Fred Gardner
Some California doctors who have taken a special interest in their patients’ cannabis
use are working towards adopting common intake procedures, definitions, and
record-keeping methods. By pooling data they hope to answer basic questions
as to what conditions people are treating with cannabis, what results they’re
getting, whether any safety problems have been identified, and so forth.
In April/May 2003 O’Shaughnessy’s put a few of these seemingly simple questions
to 10 physicians who, between them, had approved use by more than 25,000 patients.
Most responded with estimates. One requested anonymity. Tom O’Connell, MD,
reported his observations in detail (see related
article in this issue).
• How many patients have received your approval to use cannabis?
Dr. A (San Francisco): Approximately 2, 000.
Mike Alcalay, MD (Berkeley): Between 1,200 and 1,300.
David Bearman, MD (Santa Barbara): 600 to 700 unique patients.
Phillip Denney, MD (Loomis): 7,800 seen at a family-practice office now devoted
in part to monitoring cannabis use by patients.
Marian Fry, MD (Cool): Between 7,000 and 8,000. The feds have confiscated our
David Hadorn (Berkeley)): 229 (since October '02 at a clinical practice doing
primarily medical cannabis evaluations).
Jeff Hergenrather (Sebastopol): About 1,000.
Lucido (Berkeley): About 2,000 seen at a general family-practice office in
Mikuriya (Berkeley): 7,349 (At office in Oakland and clinics arranged by activists.)
O’Connell (Oakland, San Francisco): Approximately 1,800 (seen at ad hoc clinics
arranged by cannabis clubs).
Eugene Schoenfeld, MD (Sausa-lito): I don’t separate my medical MJ patients
from other patients in my (mostly) psychiatric practice. I’ve written about
500 medical MJ recommendations.
• What percentage had been self-medicating with cannabis prior to
Dr. A: More than 97 percent.
Alcalay: 99 percent.
Bearman: While most have used it before, many had stopped years ago before
starting again medically. I would estimate that 95% to 97% had been using with
benefit just prior to the visit.
Fry: All but approximately 20.
Hadorn: I can only remember one who wasn’t already using it.
O’Connell: Essentially all; most for years —or decades.
Schoenfeld: Prior to consulting me, all but one or two had been self-medicating
• With what medical conditions have they presented? List top five
and approximate percentage (total can exceed 100%).
Dr. A: Chronic pain (60%); arthritis (20%); migraine (10%); nausea (10%); anorexia
(5%); glaucoma (5%); AIDS (3%); cancer (3%); dymenorrhea (3%); irritable bowel
Alcalay: Chronic pain (50-60%); Emotional disorders (5-10%) —depression, bipolar,
situational reaction with stress, anxiety and insomnia. These are people who
would otherwise be put on Prozac-type antidepressants, sleeping pills, and
relaxants known to damage their kidneys and livers... AIDS (5%). MS, glaucoma.
A wide grab-bag.
Bearman: Pain, including muscle spasm (60-65%); nausea (15%); migraine (5%);
PTSD (3%); Irritable bowel syndrome/Crohn’s/ulcerative colitis (3-5%); Hepatitis
C with nausea and/or side effects from Interferon (1-2%(; seizures (1-2%).
A number of people have more than one problem: bipolar, depression and ADD
are rather common. Pain interfering with sleep and appetite is also commom,
as is PMS.
Denney: Chronic pain (50%); neurologic (20%); psychiatric, including ADHD and
as a “harm reduction” substitute for alcohol (15%); Gastro-intestinal (10%);
Fry: Chronic pain (80%); psychiatric disorders; hepatitis C; cancer of all
types; seizures/migraine/head injury.
Hadorn: Allowing two diagnoses per patient (many conditions occur together,
such as back and neck pain, depression and anxiety, with insomnia often woven
in): chronic back pain (81), chronic pain in shoulder, knee or other extremity,
usually due to previous injury (51); insomnia (36); headache (30, of which
11 were migraine); depression (23); anxiety (22); neck pain (22) anorexia (19).
Hergenrather: Chronic pain (50%, associated with lumbar and cervical degenerative
disk disease, traumatic major joint injuries, overuse syndromes including carpal
tunnel, cubital tunnel and tarsal tunnel syndromes; arthritis (rheumatoid,
osteoarthritis, psoriatic, gouty, Lyme’s); migraine; neuropathic pain; and
reflex sympathetic dystrophy)
Severe nausea and anorexia (20%, associated with cancer chemotherapy; hepatitis
C; treatment of HIV/AIDS, peptic ulcer disease and Barrett’s esophagitis; Chron’s
and ulcerative colitis).
Mood disorders (15%: PTSD, Anxiety and depression, Bipolar illness).
Spastic disorders (5%: quadraplegia, paraplegia, multiple sclerosis, brain
trauma, cerebral palsy).
The remainder generally use cannabis as an easement in treating ADHD, glaucoma,
asthma, harm reduction, sleep disorders (usually insomnia), and professional
Lucido: chronic pain, musculoskeletal (50%); chronic headache (5%); chronic
anxiety (5%); chronic depression (5%); PTSD (5%).
Mikuriya: Chronic pain 1,960 (27%); Spasticity 1,941 (26%); Mental Disorders
1942 (26%); Substitute for Alcohol 486 (7%); Appetite Stimulant; Hypothermogenic.
O’Connell: 1) low self-esteem (LSE); about half have ‘classic’ ADD, the others
were quiet (but usually unhappy and/or unsuccessful) in school.
2) Classic migraine —almost always associated with LSE; 3) Unequivocal pain
syndrome secondary to a post-traumatic or degenerative condition. 4) Insomnia
as a dominant complaint in someone with LSE. 5) “Poster” conditions such as
HIV, glaucoma, fibromyalgia, IBS— in the aggregate— are about fifth.
Schoenfeld: Chronic back pain, mostly due to degenerative disc disease (50-60%);
arthritis (10-20%); migraines (10%); then depression anxiety (as an adjunct
to prescribed medications), then “other,” including bipolar disorder (also
as an adjunct to prescribed medications.
• Have you encountered any out-of-the-ordinary conditions being treated
effectively with cannabis?
Dr. A: Psoriasis rash: I have two patients with real florid cases and it dramatically
decreases when they go on marijuana, and when they go off it, it gets a lot
Vertigo: it actually helps reduce the spinning sensation, not just the nausea.
And the same thing with tinnitis — in some patients, it decreases the symptom
by as much as 50 percent. They say they’re actually hearing a lot less volume.
I’m picking this up, but I’m not writing [approvals] for these indications.
Alcalay: Marfan’s Syndrome [an inherited disorder characterized by long, thin
limbs, a protruding chest wall, shortsightendness and other abnormalities].
Their joints tend to ache a lot and they say cannabis gives them both physical
and psychological relief.
Bearman: Paraplegia, paraparesis, quadriplegia (for muscle spasm, pain), phantom
limb pain, degloving of thumb, partial traumatic amputation both feet, herniated
disc, failed back surgery, s/p discectomy, s/p lumbar or cervical fusion, radiculopathy,
s/p gun shot wound to the spine, brain tumor, cancer of the colon, Tourette’s...
Denney: Too numerous to list.
Fry: Psorias/urticaria —direct application of cannabis ointment reportedly
results in decreased lesion size. Treatment of tinnitis and Meniere’s has been
reported with decrease of symptoms and increased sleep.
Hadorn: Three patients said it helped their psoriasis. So far I have seen only
one multiple sclerosis patient, only four cancer patients, and only four with
neuropathy. Four patients said it helped their asthma (cannabis is a well-known
Hergenrather: I’ve been enthusiastic about the quality-of-life changes observed
in insulin-dependent diabetics, especially Type 1. Acceptance of one’s condition,
stability of blood-sugar levels, compliance to therapy, easing of diabetic
I’ve noticed very beneficial response for renal-failure patients, dialysis-depdendent,
Impressive benefit in a dystonia case.
A significant number of patients have ended tobacco, alcohol and opiate addictions.
Lucido: MS, Parkinson’s.
Mikuriya: Review the list of ICD-9 conditions on my initial intake interview
(see list on Mikuriya's
O’Connell: Only “out of the ordinary” in that most considerations of the subject
don’t even acknowledge the existence of the low-self-esteem syndrome I believe
to be at the root of most self-medication with cannabis. The closest analogous
condition is clearly “ADD,” which is a poor surrogate because of the emphasis
placed on hyperactive disruptive behavior exhibited by (mostly male) grade-school
Schoenfeld: Two patients have told me their color blindness was improved (not
cured) by the use of cannabis.
• Your observations re safety and efficacy.
Dr. A: I’ve had rare reports of idiosyncratic hypotensive episodes [fainting
as a result of blood-pressure changes].
Alcalay: No adverse reports.
Bearman: Practically no side effects. But then again to a large extent this
is a preselected patient population.
Denney: No adverse reactions or drug interactions reported.
Fry: Occasional reports of over-sedation, panic/anxiety related to fear of
law enforcement. Ninety-five percent report very effective symptom relief,
improved quality of life, and enhanced ability to live with their disease.
Hadorn: Extremely safe and effective for virtually all patients.
Hergenrather: There have been two patients out of a thousand who tell me they
have discontinued use of cannabis because it was ineffective. About 70% of
the patients check the “very effective” box on the questionnaire, 29% check “effective,” and
1% check “somewhat effective.” I would estimate that half of all patients have
stopped taking pharmaceutical drugs once they have been able to regularly use
cannabis. Most of the remainder have reduced their use of prescription medications.
I have seen no significant adverse effects. Although my follow-up with this
population of patients is limited to about four years, the patients note that
they have been using cannabis medicinally for a longer period —five to 35 years.
Minor concerns have been expressed, on occasion, about dry mucous membranes
and drowsiness. The most frequently expressed concern involves smoking as the
method of administration. This group has substantially converted to vaporizing
and reports marked improvement in respiratory well being.
O’Connell: Those who shouldn’t use pot know it and avoid it. The people coming
in to see me know it works; their longterm use at stable dosage levels is eloquent
endorsement of both the safety and efficacy of pot.
Lucido: Extremely safe, very effective.
Mikuriya: It is remarkable how there have been no reports of adverse interactions
with any other medications. There is no comparing the safety of cannabis to
any other medication available.
Schoenfeld: Cannabis is very safe and useful, except for those using excessive
amounts by inhalation, or those with serious histories of substance abuse problems.
• To how many patients have you recommended cannabis as a treatment
Dr. A: None —my practice is not set up for psychiatric patients. But we’re
certainly seeing people using it for ADD.
Alcalay: Two or three, although many use it to quiet down and keep focused.
Bearman: Between 20 and 40.
Fry: As a primary diagnosis, approximately 50 in their early 20s, fewer than
five below age 18. As a secondary diagnosis the numbers are significant but
we do not have these figures.
Hadorn: Nine. Two patients carried a diagnosis of schizophrenia and seven with
bipolar disorder. I gave secondary diagnoses of “stress disorder” to 12 patients
whose health I felt was at risk due to the level of psychological stress they
Hergenrather: About one percent of all patients. I am being more careful to
ask about childhood behavioral problems because I find that many people give
a history consistent with ADHD even though they may not have been diagnosed
or treated for this condition.
Lucido: 20. Research should be carried out in this area.
O’Connell: The vast majority— but only if you are comfortable using “ADHD’ as
a surrogate for “low self-esteem,” which I believe to be a far more accurate
descriptor of the condition (mood disorder?) for which self-medication with
cannabis was initiated.
Schoenfeld: I have approved cannabis for ADHD about six times, again as an
adjunct to standard treatment.
• How many of your patients are consciously substituting cannabis
Dr. A: I am seeing such patients but I don’t write (recommendations) for such
Alcalay: Two to three percent (24-36).
Fry: Figures not available but an estimated 20% of male patients report reduced
alcohol intake (and inability to deal with alcohol) when questioned directly.
Many report weaning themselves from controlled substances, licit and illict,
with the use of cannabis.
Hadorn: Depends on what you mean. Many realize that they would drink more if
they didn't toke, but only a few have consciously decided to make the substitution.
I'd say 25% in former category, maybe 5-10% in latter.
Hergenrather: There are chronic pain patients who used alcohol because it numbed
the pain. They have consciously substituted cannabis for alcohol where alcohol
had become a mental and physical problem. In the case of mood-disorder patients,
alcohol was not a treatment but a problem, so cannabis is not regarded as a
substitute. The “glass -of-wine-with-dinner” patients haven’t stopped their
light, regular use of alcohol, so there has been no substitution.
Mikuriya: I have given the figure 7% but this may be revised upwards based
on a new follow-up questionnaire. The phenomen of denial has to be acknowledged.
A large number of patients, on follow-up examination, acknowledge that they
have been substituting cannabis for alcohol.
O’Connell: Most. This is also a complex issue because many of the daily users
who have opted for cannabis over alcohol found themselves to be “intolerant” —but
only after making themselves terribly sick the first two or three times they
tried to drink. This raises the question: did their quest for symptomatic relief
at age 13 or 14 cause them to actually flirt with alcohol poisoning? Also,
those who tried cannabis before alcohol may have been partially immunized against
abnormal attraction and alcoholism.
The issue of whether the patient realizes that he’s using cannabis in preference
to alcohol is somewhat separate; my interviews suggest that about 1/3 know
it, 1/3 suspected it, and 1/3 were clueless.
Schoenfeld: Many of my patients report that they use cannabis rather than alcohol,
and have thus stopped a potential alcohol ABUSE problem. However, I have found
that alcoholics much prefer alcohol to cannabis. These individuals are best
advised to use neither drug.
The reportedly successful use of cannabis as an alternative to alcohol, SSRI
antidepressants, and stimulants (in the treatment of ADHD) warrants serious,
large-scale investigation. A necessary first step is for the doctors who are
monitoring patients using cannabis for these purposes to agree on basic definitions,
diagnostic criteria, etc., and to adopt uniform record-keeping methods.
Hergenrather’s observation that half his cannabis-using patients have been
able to stop taking pharmaceutical drugs —and others have reduced their intake— suggests
a line of inquiry that belongs on a common interview form.
It appears that with very few exceptions, only people who had been self-medicating
with cannabis are availing themselves of it under California law. Legalization
has not led to a wave of naive patients with various conditions trying cannabis
to see if it might help in some way, or doctors recommending that they do so. “Approve” is
a far more accurate term than “recommend” to describe the physicians’ role
Several factors may explain the flat state of demand for a promising new medicine.
The highly publicized prosecutions of cultivators and distributors by state
and federal law enforcers has maintained an aura of illegality around cannabis.
No manufacturers have an interest in promoting its use —in fact, they have
a strong incentive to lobby for continued prohibition.
Cannabis remains hard to get and expensive ($400/ounce). Insurers don’t reimburse
for it. Corporate employers test, humiliate and fire cannabis users at will.
Almost no doctors have been educated on any aspect of cannabis —modes of delivery,
efficacy, mechanism of action, etc.— whereas all are aware that smoking involves
an assault on the lungs. Threats from the federal government, although ruled
unconstitutional, have had a chilling effect.
In subtle but significant ways, lingering Prohibition has also affected the
thousands of Californians who legally self-medicate with cannabis.
Mikuriya has observed that many problem drinkers, at their initial exams, will
emphasize conditions other than alcoholism; upon learning that substituting
cannabis for alcohol entitles them to a letter of approval, they reveal the
true severity of their drinking problem.
Similarly, O’Connell reports that many young men debilitated by ADHD with low
self-esteem will present with physical-pain problems. They are forthcoming
about beneficial psychotropic effects only after the doctor has acknowledged
the possibility of such effects.
It can be argued that a signal from the physician would inevitably skew the
interview; but the impact of prohibition is such that it may take a signal
of tolerance from the physician to begin to un-skew it.