Journal of the California Cannabis Research Medical
A Cooling Effect From Cannabis?
By Tod Mikuriya, MD
It has been observed by my office staff and confirmed anecdotally by
colleagues that people seeking physician approval to medicate with
cannabis usually register body temperatures markedly below 98.6.
Hypothermia in the mouse is one of the “classic tetrad” of
symptoms indicating activation of the cannabinoid system. The genesis
of hypothermia requires further study. The Indian Hemp Drugs Commission
observed that one of the reputed benefits was to help laborers tolerate
the heat. Cannabis was described as used to cool the passions —in
contrast with alcohol, which heated them.
A slower metabolic rate, over time, might have implications for longevity.
Clinically, cannabis appears to actually lower temperature and a couple
of patients have described a sense of cold with transient shivering.
The question could be answered readily by comparing temperatures of
persons who have THC metabolites in their urine and people who don’t.
If there turns out to be a significantly lower temperature in the cannabis-using
population, one might posit a slower metabolic rate which, over time,
might have implications for longevity. Temperature has a significant
effect on metabolic rate. We have to understand the mechanism of hypothermogenesis.
If there is a hypothermia, what influence is there on the HPA (Hypothalamus
Pituitary Adrenal networks) and all of the interactions affecting levels
of circulating cortisol and epinephrine, etc.? With management of diabetes,
cannabis decreases blood sugar by diminishing gluconeogenesis, which
plays out in decreased insulin requirement and improved stability.
This hypothermogenic effect appears to be dose-related and could contribute
to a neuroprotective effect after trauma. The optimum delivery method
will require study. Hopefully, we will see a vaporizer on ambulances
for treatment of head injury and seizures, and at the bedside of pre-
and post-neurosurgery patients.
In addition to external cooling, cannabis quiets the irritable CNS.
A combination of inhaled and oral cannabis would be appropriate for
acute CNS trauma from internal or external etiology. I predict this
will become accepted and mainstream in the future.
Raphael Mechoulam’s lab published a paper in 2003 showing that
hypothermia appears to be an important factor as to why the synthetic
THC analog HU-210 was protective in an animal model of stroke. [Leker,
R.R., Gai, N., Mechoulam, R. and Ovadia, H. (2003) Drug-induced
hypothermia reduces ischemic damage: effects of the cannabinoid HU-210.
34, 2000-2006]... If a patient presents to an ER with a stroke,
the first thing they will do is put the patient’s head in a cooler
and pump them full of antioxidants (vitamin E).